New Study: 2 FDA-Approved Drugs May Eliminate Chronic Lower Back Pain

Scientists Discover 2 Drugs That Can End Lower Back Pain

Lower back pain is one of the world’s most widespread and infuriating medical ailments—an estimated 540 million sufferers across the globe. But there could now be light at the end of the tunnel for millions following a breakthrough in the latest research. Scientists have recently found two drugs that hold out the prospect of eradicating lower back pain once and for all, with no addictive opioids or knife required.

The Breakthrough

In an early 2025 study, scientists announced that two drugs—acetazolamide and topiramate—can potentially reverse the underlying causes of chronic lower back pain. These are not new medications; both have been FDA-approved for other conditions for decades. Acetazolamide is usually prescribed for altitude sickness and glaucoma, and topiramate is used to treat epilepsy and migraines.

So how do these drugs treat back pain?

Both drugs seem to aim at inflammation of the nerves and reviving the ability of cells in the spinal discs—the soft, cushy structures that cushion the bones in the spine. The discs dehydrate and become inflamed over time, and this causes the pain many experience in their lower back. These drugs seem to stimulate disc regeneration and inflammation reduction, attacking at the root rather than easing the pain.

What This Means for Patients

The best news about this discovery is that both medications are already on the market and well-known, so their safety profiles are well established. If subsequent studies replicate these results, we could quickly see accelerated clinical use, providing patients with a non-invasive, non-addictive treatment for prolonged relief.

Though the drugs are not yet on the market for treating back pain beyond clinical trials, physicians and scientists are hopeful. The promise to replace addictive painkillers or bypass spinal surgery is a game-changer for the millions living with chronic pain every day.

Final Thoughts

This finding may be a turning point in treating chronic back pain. If you’re one of those people who’s been struggling with ongoing lower back pain, this is certainly something to watch. As always, check with your doctor before making any changes to your treatment regimen.